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  State Key Labratory of Molecular Neuroscience  
 
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Research Publications in 2016   spacer
   
  1. Au FK, Jia Y, Jiang K, Grigoriev I, Hau BK, Shen Y, Du S, Akhmanova A and Qi RZ (2016). GAS2L1 Is a Centriole-Associated Protein Required for Centrosome Dynamics and Disjunction. Dev Cell. 40(1):81-94.

  2. Chan AS, Lau WW, Szeto AC, Wang J and Wong YH (2016). Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways. J Mol Biol. 428(19):3869-84.

  3. Chan CM, Aw JT, Webb SE and Miller AL (2016). SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos. Zygote. 24(6):880-889.

  4. Chan HY, Cheung MC, Gao Y, Miller AL and Webb SE (2016). Expression and reconstitution of the bioluminescent Ca2+ reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes. (Figure used as the front cover). Sci China Life Sci. 59(8):811-24.

  5. Chen W, Lu N, Ding Y, Wang Y, Chan LT, Wang X, Gao X, Jiang S and Liu K (2016). Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion. eNeuro. 3(6).

  6. Dai Y, Zhu L, Huang Z, Zhou M, Jin W, Liu W, Xu M, Yu T, Zhang Y, Wen Z, Liao W and Zhang W (2016). Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. J Genet Genomics. 43(10):593-600.

  7. Deng H, Han T, Zhao E, Kwok R, Lam J and Tang BZ (2016). Multicomponent polymerization: development of a one-pot synthetic route to functional polymers using diyne, N-sulfonyl azide and water/ethanol as reactants. Polym Chem. 2016,7, 5646-5654.

  8. Engels JF, Roose J, Zhai DS, Yip KM, Lee MS, Tang BZ, and Renneberg R (2016). Aggregation-induced emissive nanoparticles for fluorescence signaling in a low cost paper-based immunoassay. Colloids Surf B Biointerfaces. 143:440-6.

  9. Fu AK, Hung KW, Yuen MY, Zhou X, Mak DS, Chan IC, Cheung TH, Zhang B, Fu WY, Liew FY and Ip NY (2016). IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Proc Natl Acad Sci U S A. 113(19):E2705-13.

  10. Han T, Gu X, Lam J, Leung A, Kwok R, Han T, Tong B, Shi J, Dong Y and Tang BZ (2016). Diaminomaleonitrile-based Schiff bases: aggregation-enhanced emission, red fluorescence, mechanochromism and bioimaging applications. J Mater Chem C. 2016,4, 10430-10434.

  11. Hao B, Webb SE, Miller AL and Yue J (2016). The role of Ca2+ signaling on the self-renewal and neural differentiation of embryonic stem cells (ESCs). Cell Calcium. 59(2-3):67-74.

  12. Huang S, Tang R and Poon RY (2016). BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death. Oncotarget. 7(25):38718-38730.

  13. Huang Y, Amin A, Qin Y, Wang Z, Jiang H, Liang L, Shi L and Liang C (2016). A Role of hIPI3 in DNA Replication Licensing in Human Cells. PLoS One. 11(4):e0151803.

  14. Hui CW, Zhang Y and Herrup K (2016). Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from α Neuron-Enriched Culture System. PLoS One. 11(1):e0147134.

  15. Ip FC, Zhao YM, Chan KW, Cheng EY, Tong EP, Chandrashekar O, Fu GM, Zhao ZZ and Ip NY (2016). Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats. BMC Complement Altern Med. 16(1):437.

  16. Jin G, Feng G, Qin W, Tang BZ, Liu B and Li K (2016). Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem Commun (Camb). 52(13):2752-5.

  17. Jin H, Huang Z, Chi Y, Wu M, Zhou R, Zhao L, Xu J, Zhen F, Lan Y, Li L, Zhang W, Wen Z and Zhang Y (2016). c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128(3):415-26.

  18. Leclerc C, Haeich J, Aulestia FJ, Kilhoffer MC, Miller AL, Néant I, Webb SE, Schaeffer E, Junier MP, Chneiweiss H and Moreau M (2016). Calcium signaling orchestrates glioblastoma development: Facts and conjunctures. Biochim Biophys Acta. 1863(6 Pt B):1447-59.

  19. Leung A, Zhao E, Kwok R, Lam J, Leung C, Deng H and Tang BZ (2016). An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2. J Mater Chem B. 2016,4, 5510-5514.

  20. Leung CW, Wang Z, Zhao E, Hong Y, Chen S, Kwok RT, Leung AC, Wen R, Li B, Lam JW and Tang BZ (2016). A Lysosome-Targeting AIEgen for Autophagy Visualization. Adv Healthc Mater. 5(4):427-31.

  21. Li H, Xue S, Su H, Shen B, Cheng Z, Lam JW, Wong KS, Wu H, Li BS and Tang BZ (2016). Click Synthesis, Aggregation-Induced Emission and Chirality, Circularly Polarized Luminescence, and Helical Self-Assembly of a Leucine-Containing Silole. Small. 12(47):6593-6601.

  22. Li H, Zheng X, Su H, Lam JW, Sing Wong K, Xue S, Huang X, Huang X, Li BS and Tang BZ (2016). Synthesis, optical properties, and helical self-assembly of a bivaline-containing tetraphenylethene. Sci Rep. 6:19277.

  23. Li J, He Y, Lu Q and Zhang M (2016). Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex. Dev Cell. 36(2):179-89.

  24. Li J, Lu Q and Zhang M (2016). Structural Basis of Cargo Recognition by Unconventional Myosins in Cellular Trafficking. (Invited review). Traffic. 17(8):822-38.

  25. Li PP, Sun X, Xia G, Arbez N, Paul S, Zhu S, Peng HB, Ross CA, Koeppen AH, Margolis RL, Pulst SM, Ashizawa T and Rudnicki DD (2016). ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis. Ann Neurol. 80(4):600-15.

  26. Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y and Liu K (2016). Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proc Natl Acad Sci U S A. 113(7):1937-42.

  27. Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO and Ip NY (2016). The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 7:13282.

  28. Lin H, Chen S, Hu H, Zhang L, Ma T, Lai JY, Li Z, Qin A, Huang X, Tang BZ and Yan H (2016). Reduced Intramolecular Twisting Improves the Performance of 3D Molecular Acceptors in Non-Fullerene Organic Solar Cells. Adv Mater. 28(38):8546-8551.

  29. Liu H, Li J, Raval MH, Yao N, Deng X, Lu Q, Nie S, Feng W, Wan J, Yengo CM, Liu W and Zhang M (2016). Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin. Elife. 5. pii: e12856.

  30. Liu S, Zhu L, Sheong FK, Wang W and Huang X (2016). Adaptive partitioning by local density-peaks: An efficient density-based clustering algorithm for analyzing molecular dynamics trajectories. J Comput Chem. 38(3):152-160.

  31. Lo CY, Chen S, Creed SJ, Kang M, Zhao N, Tang BZ and Elgass KD (2016). Novel super-resolution capable mitochondrial probe, MitoRed AIE, enables assessment of real-time molecular mitochondrial dynamics. Sci Rep. 6:30855.

  32. Ma HT and Poon RY (2016). TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint. Cell Rep. 14(5):1086-99.

  33. Moreau M, Néant I, Webb SE, Miller AL, Riou JF and Leclerc C (2016). Ca2+ coding and decoding strategies for the specification of neural and renal precursor cells during development. Cell Calcium. 59(2-3):75-83.

  34. Poo MM, Du JL, Ip NY, Xiong ZQ, Xu B and Tan T (2016). China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing. Neuron. 92(3):591-596.

  35. Roose J, Tang BZ and Wong KS (2016). Circularly-Polarized Luminescence (CPL) from Chiral AIE Molecules and Macrostructures. Small. 12(47):6495-6512.

  36. Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, Sweeney HL and Houdusse A (2016). The myosin X motor is optimized for movement on actin bundles. Nat Commun. 7:12456.

  37. Shen Y, Guan D, Serien D, Takeuchi S, Tong P, Yobas L and Huang P (2016). Mechanical Characterization of Microengineered Epithelial Cysts by Using Atomic Force Microscopy. Biophys J. 112(2):398-409.

  38. Shen Y, Tian M, Zheng Y, Gong F, Fu AK and Ip NY (2016). Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer's Disease Model. Cell Rep. 17(7):1819-1831.

  39. Song JX, Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL, Guo Z and Li M (2016). A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 12(8):1372-89.

  40. Song Z, Kwok RT, Ding D, Nie H, Lam JW, Liu B and Tang BZ (2016). An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection of hydrogen peroxide and glucose. Chem Commun (Camb). 52(65):10076-9.

  41. Song Z, Zhang W, Jiang M, Sung H, Kwok R, Nie H, Williams I, Liu B and Tang BZ (2016). Synthesis of Imidazole-Based AIEgens with Wide Color Tunability and Exploration of their Biological Applications. Adv Funct Mater. 2016, 26(6): 824-832.

  42. Sun YP and Huang (2016). Adenosine A2B Receptor: From Cell Biology to Human Diseases. Front Chem. 4:37.

  43. Sun Y, Hu W, Yu X, Liu Z, Tarran R, Ravid K and Huang P (2016). Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression. Biochem J. 473(14):2179-86.

  44. Tang G, Liu X, Ma N, Huang X, Wu ZL, Zhang W, Wang Y, Zhao BX, Wang ZY, Ip FC, Ip NY, Ye WC, Shi L and Chen WM (2016). Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities. ACS Chem Neurosci. 7(10):1442-1451.

  45. Vail G, Cheng A, Han YR, Zhao T, Du S, Loy MM, Herrup K and Plummer MR (2016). ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity. J Neurophysiol. 116(1):201-9.

  46. Wang YJ, Shi Y, Wang Z, Zhu Z, Zhao X, Nie H, Qian J, Qin A, Sun JZ and Tang BZ (2016). A Red to Near-IR Fluorogen: Aggregation-Induced Emission, Large Stokes Shift, High Solid Efficiency and Application in Cell-Imaging. Chemistry. 22(28):9784-91.

  47. Wang Z, Bai W, Tong J, Wang YJ, Qin A, Sun JZ and Tang BZ (2016). A macrocyclic 1,4-bis(4-pyridylethynyl)benzene showing unique aggregation-induced emission properties. Chem Commun (Camb). 52(68):10365-8.

  48. Wei Y, Xu J, Zhang W, Wen Z and Liu F (2016). RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development. 143(12):2103-10.

  49. Wei Z, Xu Z, Liu X, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang M and Schimmel P (2016). Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. Nucleic Acids Res. 44(3):1247-55.

  50. Willenberg R, Zukor K, Liu K, He Z and Steward O (2016). Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down. J Comp Neurol. 524(13):2654-76.

  51. Wong PY, Ma HT, Lee HJ and Poon RY (2016). MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation. Sci Rep. 6:22230.

  52. Xie C, Cao X, Chen X, Wang D, Zhang WK, Sun Y, Hu W, Zhou Z, Wang Y and Huang P (2016). Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia. FASEB J. 30(4):1579-89.

  53. Xie HQ, Xu T, Chen Y, Li Y, Xia Y, Xu SL, Wang L, Tsim KW and Zhao B (2016). New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chem-Biol Interact. 259(Pt B):286-290.

  54. Xiong A, Yan AL, Bi CW, Lam KY, Chan GK, Lau KK, Dong TT, Lin H, Yang L, Wang Z and Tsim KW (2016). Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells. Phytomedicine. 23(9):931-8.

  55. Xu D, Chen H, Mak S, Hu S, Tsim KW, Hu Y, Sun Y, Zhang G, Wang Y, Zhang Z and Han Y (2016). Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochem Int. 99:194-205.

  56. Xu J, Wang N, Luo JH and Xia J (2016). Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons. Sci Rep. 6:20924.

  57. Xu J, Wang T, Wu Y, Jin W and Wen Z (2016). Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Dev Cell. 38(2):214-22.

  58. Yang L, Lee MM, Leung MM and Wong YH (2016). Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion. Cell Signal. 28(11):1663-72.

  59. Ye F, Liu W, Shang Y and Zhang M (2016). An Exquisitely Specific PDZ/Target Recognition Revealed by the Structure of INAD PDZ3 in Complex with TRP Channel Tail. [Cover article]. Structure. 24(3):383-91.

  60. Yu RJ, Liu HB, Yu Y, Liang L, Xu R, Liang C, Tang JS and Yao XS (2016). Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics. Fitoterapia. 112:175-82.

  61. Yu T, Guo W, Tian Y, Xu J, Chen J, Li L and Wen Z (2016). Distinct regulatory networks control the development of macrophages of different origins in zebrafish. Blood. 129(4):509-519.

  62. Zeng M, Shang Y, Guo T, He Q, Yung WH, Liu K and Zhang M (2016). A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function. Proc Natl Acad Sci U S A. 113(22):E3081-90.

  63. Zeng M, Shang Y, Araki Y, Guo T, Huganir RL and Zhang M (2016). Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity. Cell. 166(5):1163-1175.

  64. Zhang L, Jiang H, Sheong FK, Pardo-Avila F, Cheung PP and Huang X (2016). Constructing Kinetic Network Models to Elucidate Mechanisms of Functional Conformational Changes of Enzymes and Their Recognition with Ligands. Methods Enzymol. 578:343-71.

  65. Zhang L, Pardo-Avila F, Unarta IC, Cheung PP, Wang G, Wang D and Huang X (2016). Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network Models. Acc Chem Res. 49(4):687-94.

  66. Zhao T, Lau SC, Wang Y, Su Y, Wang H, Cheng A, Herrup K, Ip NY, Du S and Loy MM (2016). Multicolor 4D Fluorescence Microscopy using Ultrathin Bessel Light Sheets. Sci Rep. 6:26159.

  67. Zhou L, Ma SL, Yeung PK, Wong YH, Tsim KW, So KF, Lam LC and Chung SK (2016). Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac. Transl Psychiatry. 6(9):e881.

  68. Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z and Feng G (2016). Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects. Neuron. 89(1):147-62.

  69. Zhu H, Xiao F, Wang G, Wei X, Jiang L, Chen Y, Zhu L, Wang H, Diao Y, Wang H, Ip NY, Cheung TH and Wu Z (2016). STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. Cell Rep. 16(8):2102-15.

  70. Zhu J, Shang Y, Xia Y, Zhang R and Zhang M (2016). An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B. Structure. 24(11):1876-1885.

  71. Zhu J, Shang Y and Zhang M (2016). Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling. (Invited review). Nat Rev Neurosci. 17(4):209-23.

 
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  The State Key Laboratory of Neuroscience aims to become one of the world’s leading research hub in neuroscience research. From Bench to Bedside - Towards The Treatment of Debilitating Neurological Disorders Through The Discovery of Novel Neuro-Drugs.  
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