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Research Publications in 2012   spacer
  1. Chan WK, Chen VP, Luk WK, Choi RC and Tsim KW (2012). N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase. Neurosci. Lett. 523:71-5.

  2. Chen L, Liu C, Ko FCF, Xu N, Ng IOL, Yam JWP and Zhu G (2012). Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. J. Biol. Chem. 287(31):26104-26114.

  3. Chen SJ, Liu JZ, Liu Y, Su HM, Hong YN, Jim CKW, Kwok RTK, Zhao N, Qin W, Lam JWY, Wong KS and Tang BZ  (2012). An AIE-active hemicyanine fluorogen with stimuli-responsive red/blue emission: extending the pH sensing range by ‘‘switch + knob’’ effect. Chem. Sci. 3:1804-1809.

  4. Chen Y, Fu AKY and Ip NY  (2012). Eph receptors at synapses: Implications in neurodegenerative diseases. Cell. Signal. 24:606-611. Invited.

  5. Chen Y, Fu WY, Ip JP, Ye T, Fu AKY, Chao MV and Ip NY (2012). Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development. J Neurosci. 32:8263-8269.

  6. Cheung ZH and Ip NY  (2012). Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol. 22:169-175. Invited.

  7. Cheung ZH and Ip NY (2012). Cyclin-Dependent Kinase 5 – An Emerging Player in Parkinson’s Disease Pathophysiology. Mechanisms in Parkinson’s Disease – Models and Treatments. 7:141-156.

  8. Diao Y, Guo X, Li Y, Sun K, Lu L, Jiang L, Fu X, Zhu H, Sun H, Wang H and Wu Z (2012). Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. Cell Stem Cell.11:231-41.

  9. Duan Y, Sun Y, Zhang F, Zhang W, Wang D, Wang Y, Cao X, Hu W, Xie C, Cuppoletti J, Magin T, Wang H, Wu Z, Li N and Huang P (2012). Keratin 18 increases CFTR surface expression by binding to its C-terminal hydrophobic patch. J. Biol. Chem. 287(48):40547-59.

  10. Geng JL, Li K, Ding D, Zhang X, Qin W, Liu JZ, Tang BZ  and Liu B (2012). Lipid-PEG-Folate encapsulated nanoparticles with aggregation induced emission characteristics: Cellular uptake mechanism and two-photon fluorescence imaging. Small. 8(23):3655-63.

  11. Hoffmann F, Muller W, Schutz D, Penfold ME, Wong YH, Schulz S and Stumm R (2012). Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal Serine/Threonine residues. J. Biol. Chem. 287:28362-28377.

  12. Hong YN, Meng LM, Chen S, Leung CWT, Da LT, Faisal M, Silva DA, Liu JZ, Lam JWY, Huang XH and Tang BZ  (2012). Monitoring and inhibition of insulin fibrillation by a small organic fluorogen with aggregation-induced emission characteristics. J. Am. Chem Soc. 134:1680-1689.

  13. Hu RR, Lam JWY, Liu JZ, Sung HHY, Williams ID, Yue ZN, Wong KS, Yuen MMF and Tang BZ  (2012). Hyperbranched conjugated poly(tetraphenylethene): synthesis, aggregation-induced emission, fluorescent photopatterning, optical limiting and explosive detection. Polym. Chem. 3:1481-1489.

  14. Huo L, Wu R, Yu Z, Zhai Y, Yang X, Chan TC, Yeung JT, Kan J and Liang C  (2012). The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle. 11(7):1325-39.

  15. Huo L, Yue Y, Yu J, Yu Y, Ye F, Xu T, Zhang M and Feng W (2012). The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A. Structure. 20:1550-1561.

  16. Ip AKC, Tso PH, Lee MMK and Wong YH (2012). Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum. Mol. & Cell. Biochem. 362:159-168.

  17. Ip JP, Shi L, Chen Y, Itoh Y, Fu WY, Betz A, Yung WH, Gotoh YY, Fu AK and Ip NY (2012). alpha2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat. Neurosci. 15:39-47.

  18. Jia M, Li J, Zhu J, Wen W, Zhang M and Wang W (2012). Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gαi J. Biol. Chem. 287(44):36766-76.

  19. Jia M, Li J, Zhu J, Wen W, Zhang M and Wang W (2012). Structure and biochemical characterizations of LGN GoLoco/Gai interaction suggest scaffolding and Ga signaling roles of LGN in asymmetric cell division. J. Biol. Chem. DOI: 10.1074/jbc.M112.391607.

  20. Jim CKW, Lam JWY, Qin AJ, Leung CWT, Liu JZ, Sung HHY, Williams ID and Tang BZ (2012). Ferrocene-decorated hyperbranched Poly (arosycarbonyl- phenylene)s: Synthesis, light refraction, photopatterning and precursor to magnetic ceramics. J. Inorg. Organomet. Polym. DOI: 10.1007/s10904-012- 9727-3.

  21. Jim CKW, Lam JWY, Qin AJ, Zhao ZJ, Liu JZ, Hong YN and Tang BZ (2012). Luminescent and light refractive polymers: Synthesis and optical and photonic properties of poly(arylene ethynylene)s carrying silole and tetraphenylethene luminogenic units. Macromol. Rapid Commun. 33:568-572.

  22. Jin H, Li L, Xu J, Zhen F, Zhu L, Liu P, Zhang M, Zhang W and Wen Z (2012). Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop that confines Pu.1 expression. Blood. 119:5239-5249.

  23. Kwan DHT, Ye RD and Wong YH (2012). Activation of Ras-dependent signaling pathways by G14-coupled receptors requires the adaptor protein TPR1. J. Cell. Biochem. 113:3486-3497.

  24. Lai KO and Ip NY (2012). Eph receptor. Encyclopedia of Signaling Molecules. Springer. 560-567. Invited.

  25. Lai KO, Wong AS, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH and Ip NY (2012). TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat. Neurosci. 15(11):1506-1515.

  26. Lam JWY, Qin A, Dong Y, Liu J, Jim CKW, Hong Y, Kwok HS and Tang BZ (2012). Carbazole-functionalised poly(1-phenyl-1-alkyne)s: Synthesis, light emission, and fluorescent photopattrning. Aust. J. Chem. 65:1228-1237.

  27. Lau WWI, Ng JKY, Chan ASL and Wong YH (2012). Interleukin-6 autocrine signaling mediates melatonin MT1/2 receptor-induced STAT3 Tyr705 phosphorylation. J Pineal Res. 52:477-489.

  28. Lee MMK, Chui RKS, Tam YS, Lau HYA and Wong YH (2012). CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Gα14/16 signaling and interleukin-6 release. J. Immunol. 189(11):5266-76.

  29. Li HK, Wang J, Sun JZ, Hu RR, Qin AJ and Tang BZ (2012). Metal-free click polymerization of propiolates and azides: facile synthesis of functional poly(aroxycarbonyltriazole)s. Polym. Chem. 3:1075-1083.

  30. Li L, Yan B, Shi YQ, Zhang WQ and Wen ZL (2012). Live imaging reveals differing roles of macrophages and neutrophils during zebrafish tail fin regeneration. J. Biol. Chem. 287:25353-25360.

  31. Li X, Funderburk SF, Che KH, Pan L, Zhang M, Yue Z and Zhao Y (2012). Imperfect and metastable dimer interface of Beclin 1 coiled coil domain is critical for association with Atg14L and UVRAG. Nat. Commun. 3:662.

  32. Li X, He L, Zhang M, Yue Z and Zhao Y (2012). The Beclin 1 coiled coil domain: an “imperfect” homodimer interface that facilitates Atg14L and UVRAG binding. Autophagy. 8:1258-1260.

  33. Li X, Lan Y, Xu J, Zhang WQ and Wen ZL (2012). SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development. 139:4321-4329.

  34. Li Y, Du XF, Wen ZL and Du JL (2012). Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev. Cell. 23:1189-1202.

  35. Liu CD, Wu R, Zhou B, Wang JF, Wei Z, Tye BK, Liang C and Zhu G (2012). Structural insights into the Cdt1-mediated MCM2–7 chromatin loading. Nucleic Acids Res. 40(7):3208-3217.

  36. Liu JZ, Su H, Meng L, Zhao Y, Deng C, Ng JCY, Lu P, Faisal M, Lam JWY, Huang X, Wu H, Wong KS and Tang BZ (2012). What makes efficient circularly polarized luminescence in the condensed phase: Aggregation-induced circular dichroism and light emission. Chem. Sci. 3:2737-2747.

  37. Lu Q, Ye F, Wei Z, Wen Z and Zhang M (2012). Antiparallel coiled coil-mediated dimerization of myosin X. Proc. Natl. Acad. Sci. USA. 109:17388-17393.

  38. Luk WK, Chen VP, Choi RC and Tsim KW (2012). N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting. FEBS J. 279:3229-39.

  39. Luo Y, Cao X, Huang P and Yobas L (2012). Microcapillary-assisted dielectrophoresis (μC-DEP) for single-aprticle positioning. Lab Chip. 12:4085-4092.

  40. Mei J, Tong J, Wang J, Qin A, Sun JZ and Tang BZ (2012). Discriminative fluorescence detection of cysteine, homocysteine and glutathione via reaction-dependent aggregation of fluorophore-analyte adducts. J. Mater. Chem. 22:17063-17070.

  41. Pan L and Zhang M (2012). A structural biology perspective of the usher syndrome I protein complex assembly. Physiology. 27:25-42. Invited review.

  42. Qin AJ, Zhang Y, Han N, Mei J, Sun JZ, Fan WM and Tang BZ (2012). Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics. Sci. China Chem. 55:772-778.

  43. Shi HB, Liu JZ, Geng JL, Tang BZ and Liu B (2012). Specific detection of integrin αvβ3 by light-up bioprobe with aggregation-induced emission characteristics. J. Am. Chem. Soc. 134(23):9569-9572.

  44. Shi L, Fu AKY and Ip NY (2012). Molecular mechanisms underlying the maturation and maintenance of the vertebrate neuromuscular junction. Trends Neurosci. 35(7):441-453.

  45. Sun Y, Duan Y, Eisenstein AS, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid K and Huang P (2012). A novel mechanism of control of NFκB activation and inflammation involving A_2B adenosine receptors. J. Cell Sci. 125:4507-17.

  46. Wan OW and Chung KKK (2012). The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson’s disease. PLoS One. 7(6):e38545. 1-14.

  47. Wang C, Shang Y, Yu J and Zhang M (2012). Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCι in complex with a substrate peptide from Par-3. Structure. 20:791-801.

  48. Wang C, Yu C, Ye F, Wei Z and Zhang M (2012). Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. Proc. Natl. Acad. Sci. USA. 109:4822-4827.

  49. Wang J, Mei J, Hu RR, Sun JZ, Qin AJ and Tang BZ (2012). Click synthesis, aggregation-induced emission, E-Z isomerization, self-organization, and multiple chromisms of pure stereoisomers of a tetraphenylethene-cored luminogen. J. Am. Chem. Soc. 134:9956-9966.

  50. Wang J, Mei J, Zhao E, Song Z, Qin A, Sun JZ and Tang BZ (2012). Ethynyl-capped hyperbranched conjugated polytriazole: click polymerization, clickable modification, and aggregation-enhanced emission. Macromolecules. 45:7692-7703.

  51. Webb SE and Miller AL (2012). Aequorin-based genetic approaches to visualize Ca2+ signaling in developing animal systems. Biochim. Biophys. Acta. 1820(8):1160-1168.

  52. Webb SE, Cheung CY, Chan CM, Love DR and Miller AL (2012). Application of complementary luminescent and fluorescent imaging techniques to visualize nuclear and cytoplasmic Ca²⁺ signalling during the in vivo differentiation of slow muscle cells in zebrafish embryos under normal and dystrophic conditions. Clin. Exp. Pharmacol. Physiol. 39(1):78-86.

  53. Wei Q, Deng HQ, Cai YB, Lam WY, Li J, Sun JZ, Gao M, Qin AJ and Tang BZ (2012). Efficient polymerization of azide and active internal alkynes. Macromol. Rapid Commun. 33:1356-1361.

  54. Wu L, Pan L, Zhang C and Zhang M (2012). Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. J. Biol. Chem. 287:33460-33471.

  55. Xiao F, Wang H, Fu X, Li Y and Wu Z (2012). TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and Akt pathways. PLoS ONE. 7(4):e34081.

  56. Xie W and Chung KKK (2012). Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease. J. Neurochem. 122:404-414.

  57. Xu Z, Wei Z, Zhou J, Ye F, Lo CWS, Wu J, Wang F, Lau CCF, Nangle L, Chiang KP, Yang XL, Zhang M and Schimmel P (2012). Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. Structure. 20:1470-1477.

  58. Ye T, Fu AKY and Ip NY (2012). Cyclin-dependent kinase 5 in axon growth and regeneration. Int. Rev. Neurobiol. 105:91-115.

  59. Yu C, Lou J, Wu J, Pan L, Feng W and Zhang M (2012). Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes. J. Biol. Chem. 287:35021-35035.

  60. Yuan WZ, Gong Y, Chen S, Shen XY, Lam JWY, Lu P, Lu Y, Wang Z, Hu R, Xie N, Kwok HS, Zhang Y, Sun JZ and Tang BZ (2012). Efficient solid emitters with aggregation-induced emission and intramolecular charge transfer characteristics: Molecular design, synthesis, photophysical behaviors, and OLED application.. Chem. Mater. 24:1518-1528.

  61. Yuan WZ, Hu RR, Lam JWY, Xie N, Jim CKW and Tang BZ (2012). Conjugated hyperbranched poly(arACHTUNGTRENUNGyleneethynylene)s: synthesis, photophysical properties, superquenching by explosive, photopatternability, and tunable high refractive indices. Chem. Eur. J. 18:2847-2856.

  62. Yuan WZ, Mahtab F, Gong YY, Yu ZQ, Lu P, Tang YH, Lam JWY, Zhu CZ and Tang BZ (2012). Synthesis and self-assembly of tetraphenylethene and biphenyl based AIE-active triazoles. J. Mater. Chem. 22:10472-10479.

  63. Yuan WZ, Yu ZQ, Lu P, Deng C, Lam JWY, Wang ZM, Chen EQ, Ma YG and Tang BZ (2012). High efficiency luminescent liquid crystal: aggregation-induced emission strategy and biaxially oriented mesomorphic structure. J. Mater. Chem. 22:3323-3326.

  64. Yuan WZ, Yu ZQ, Tang YH, Lam JWY, Xie N, Lu P, Chen EQ and Tang BZ (2012). High solid-state efficiency fluorescent main chain liquid crystalline polytriazoles with aggregation-induced emission characteristics. Macromolecules. 44(24):9618-9628.

  65. Yuen MYF, Webb SE, Chan CM, Thisse B, Thisse C and Miller AL (2012). Characterization of Ca2+ signaling in the external yolk syncytial layer during the late blastula and early gastrula periods of zebrafish development. BBA – Mol. Cell Res. In press.

  66. Zeng Y, Xu J, Li D, Li L, Wen ZL and Qu JY (2012). Label-free in vivo flow cytometry in zebrafish using two-photon autofluorescence imaging. Opt. Lett. 37:2490-2492.

  67. Zhang XA, Qin AJ, Tong L, Zhao H, Zhao QL, Sun JZ and Tang BZ (2012). Synthesis of functional disubstituted polyacetylenes bearing highly polar functionalities via activated ester strategy. ACS Macro Lett. 1:75-79.

  68. Zhao N, Yang Z, Lam JWY, Sung HHY, Xie N, Chen S, Su H, Gao M, Williams ID, Wong KS and Tang BZ (2012). Benzothiazolium-functionalized tetraphenylethene: An AIE luminogen with tunable solide-state emission. Chem. Commun. 48:8637-8639.

  69. Zhao Q, Zhang S, Liu Y, Mei J, Chen S, Lu P, Qin A, Ma Y, Sun JZ and Tang BZ (2012). Tetraphenylethenyl-modified perylene bisimide: aggregation-induced red emission, electrochemical properties and ordered microstructures. J. Mater. Chem. 22:7387-7394.

  70. Zhao Q, Zhang XA, Wei Q, Wang J, Shen XY, Qin A, Sun JZ and Tang BZ (2012). Tetraphenylethene modified perylene bisimide: Effect of the number of substituent on AIE performance. Chem. Commun. 48:11671-11673.

  71. Zhao QL, Li K, Chen SJ, Qin AJ, Ding D, Zhang S, Liu Y, Liu B, Sun JZ and Tang BZ (2012). Aggregation-induced Red-NIR emission organic nanoparticles as effective and photostable fluorescent probe for bioimaging. J. Mater. Chem. 22:15128-15135.

  72. Zhao Z, Geng J, Chang Z, Chen S, Deng C, Jiang T, Qin W, Lam JWY, Kwok HS, Qiu H, Liu B and Tang BZ (2012). A tetraphenylethene-based red luminophor for an efficient non-doped electroluminescence device and cellular imaging. J. Mater. Chem. 22:11018-11021.

  73. Zhao Z, Jiang T, Guo Y, Ding L, He B, Chang Z, Lam JWY, Liu J, Chan CYK, Lu P, Xu L, Qiu H and Tang BZ (2012). Silole-containing poly(silylenevinylene)s: Synthesis, characterization, aggregation-enhanced emission, and explosive detection. J. Polym. Sci. A Polym. Chem. 50: 2265-2274.

  74. Zhao ZJ, Chan CYK, Chen SM, Deng CM, Lam JWY, Jim CKW, Hong YN, Lu P, Chang ZF, Chen XP, Lu P, Kwok HS, Qiu HY and Tang BZ (2012). Using tetraphenylethene and carbazole to create efficient luminophores with aggregation-induced emission, high thermal stability, and good hole-transporting property. J. Mater. Chem. 22:4527-4534.

  75. Zhao ZJ, Guo YJ, Jiang T, Chang ZF, Lam JWY, Xu LW, Qiu HY and Tang BZ (2012). A fully substituted 3-silolene functions as promising building block for hyperbranched poly(Silylenevinylene). Macromol. Rapid Commun. 33:1074-1079.

  76. Zhou B, Liu C, Xu Z and Zhu G (2012). Structural basis for homeodomain recognition by the cell-cycle regulator Geminin. Proc. Natl. Sci. USA. 109:8931-8936.

  77. Zhu J, Hu Y, Ho MKC and Wong YH (2012). Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats. Xenobiotica. 42(11)1138-1150.

  78. Zhu J, Shang Y, Chen J and Zhang M (2012). Structure and function of the guanylate kinase-like domain of the MAGUK family scaffold proteins. Front Biol. 7:379-396. Invited review.

  79. Zhu KY, Mao QQ, Ip SP, Choi RC, Dong TT, Lau DT and Tsim KW (2012). A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats. Evid-Based Compl. Alt. 2012:149256.

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