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  State Key Labratory of Molecular Neuroscience  
 
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Research Publications in 2015   spacer
   
  1. Barnes M, van Rensburg G, Li WM, Mehmood K, Mackedenski S, Chan CM, King DT, Miller AL and Lee CH (2015). Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains. J Biol Chem. 290(1):625-39.

  2. Chen S, Hong Y, Zeng Y, Sun Q, Liu Y, Zhao E, Bai G, Qu J, Hao J and Tang BZ (2015). Mapping live cell viscosity with an aggregation-induced emission fluorogen by means of two-photon fluorescence lifetime imaging. Chemistry. 21(11):4315-20.

  3. Chen Y, Liang Z, Fei E, Chen Y, Zhou X, Fang W, Fu WY, Fu AK and Ip NY (2015). Axin regulates dendritic spine Morphogenesis through Cdc42-Dependent signaling. PLoS One. 10(7):e0133115.

  4. Chen Y, Sun Y, Song H and Guo Z (2015). Structural basis for the ATP-dependent configuration of Adenylation active site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase. J Biol Chem. 290(39):23971-83.

  5. Chow HM and Herrup K (2015). Genomic integrity and the ageing brain. Nat Rev Neurosci. 16(11):672-84.

  6. Ding Y, Yang M, Yang Z, Luo R, Lu X, Huang N, Huang P and Leng Y (2015). Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography. Acta Biomater. 15:150-63.

  7. Dong YQ, Lam JW and Tang BZ (2015). Mechanochromic luminescence of aggregation-induced emission luminogens. J Phys Chem Lett. 18:3429-3436.

  8. Du K, Zheng S, Zhang Q, Li S, Gao X, Wang J, Jiang L and Liu K (2015). Pten deletion promotes regrowth of corticospinal tract axons 1 year after spinal cord injury. J Neurosci. 35(26):9754-63.

  9. Fu AK and Ip NY (2015). Neddylation is needed for synapse maturation. Nat Neurosci. 18(2):164-6.

  10. Gomez-Duran CF, Hu R, Feng G, Li T, Bu F, Arseneault M, Liu B, Peña-Cabrera E and Tang BZ (2015). Effect of AIE substituents on the fluorescence of tetraphenylethene-containing BODIPY derivatives. ACS Appl Mater Interfaces. 7(28):15168-76.

  11. He J, Xia M, Tsang WH, Chow KL and Xia J (2015). ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. J Cell Sci. 128(20):3822-36.

  12. Herrup K (2015). The case for rejecting the amyloid cascade hypothesis. Nat Neurosci. 18(6):794-9.

  13. Ip FC, Fu WY, Cheng EY, Tong EP, Lok KC, Liang Y, Ye WC and Ip NY (2015). Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection. Neuropsychopharmacology. 40(8):1877-87.

  14. Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y, Wen W and Wang W (2015). The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nat Commun. 6:8381.

  15. Jiang D, Zhang Y, Hart RP, Chen J, Herrup K and Li J (2015). Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain. 138(Pt 12):3520-36.

  16. Kim YS, Yang M, Mat WK, Tsang SY, Su Z, Jiang X, Ng SK, Liu S, Hu T, Pun F, Liao Y, Tang J, Chen X, Hao W and Xue H (2015). GABRB2 Haplotype association with Heroin dependence in Chinese population. PLoS One. 10(11):e0142049.

  17. Lai KO, Liang Z, Fei E, Huang H and Ip NY (2015). Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) is required for dendritic spine morphogenesis. J Biol Chem. 290(23):14637-46.

  18. Leung CW, Wang Z, Zhao E, Hong Y, Chen S, Kwok RT, Leung AC, Wen R, Li B, Lam JW and Tang BZ (2015). A lysosome-targeting AIEgen for autophagy visualization. Adv Healthc Mater. 5(4):427-31.

  19. Li J, Hong MJ, Chow JP, Man WY, Mak JP, Ma HT and Poon RY (2015). Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. Oncotarget. 6(11):9327-40.

  20. Li J, Jiang Y, Cheng J, Zhang Y, Su H, Lam JW, Sung HH, Wong KS, Kwok HS and Tang BZ (2015). Tuning the singlet-triplet energy gap of AIE luminogens: crystallization-induced room temperature phosphorescence and delay fluorescence, tunable temperature response, highly efficient non-doped organic light-emitting diodes. Phys Chem Chem Phys. 17(2):1134-41.

  21. Li J, Zhang Y, Mei J, Lam JW, Hao J and Tang BZ (2015). Aggregation-induced emission rotors: rational design and tunable stimuli response. Chemistry. 21(2):907-14.

  22. Li S, He Q, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH and Liu K (2015). Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiol Dis. 73:366-76.

  23. Li Y, Zhou H, Li F, Chan SW, Lin Z, Wei Z, Yang Z, Guo F, Lim CJ, Xing W, Shen Y, Hong W, Long J and Zhang M (2015). Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway. Cell Res. 25(7):801-17.

  24. Li Z, Ip FC, Ip NY and Tong R (2015). Highly trans-selective arylation of Achmatowicz rearrangement products by reductive γ-deoxygenation and Heck-Matsuda reaction: asymmetric total synthesis of (-)-musellarins A-C and their analogues. Chemistry. 21(31):11152-7.

  25. Liang Z, Ye T, Zhou X, Lai KO, Fu AK and Ip NY (2015). Cdk5 regulates activity-dependent gene expression and dendrite development. J Neurosci. 35(45):15127-34.

  26. Lorenzo DN, Healy JA, Hostettler J, Davis J, Yang J, Wang C, Hohmeier HE, Zhang M and Bennett V (2015). Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. J Clin Invest. 125(8):3087-102.

  27. Lu Q, Li J, Ye F and Zhang M (2015). Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat Struct Mol Biol. 22(1):81-8.

  28. Mak JP, Man WY, Chow JP, Ma HT and Poon RY (2015). Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells. Oncotarget. 6(25):21074-84.

  29. Mei J, Leung NL, Kwok RT, Lam JW and Tang BZ (2015). Aggregation-Induced emission: Together we shine, United we soar! Chem Rev. 115(21):11718-940.

  30. Moreau M, Néant I, Webb SE, Miller AL, Riou JF and Leclerc C (2015). Ca2+ coding and decoding strategies for the specification of neural and renal precursor cells during development. Cell Calcium. S0143-4160(15)00174-8.

  31. Ng YP, Or TC and Ip NY (2015). Plant alkaloids as drug leads for Alzheimer's disease. Neurochem Int. 89:260-70.

  32. Nie H, Chen B, Quan C, Zhou J, Qiu H, Hu R, Su SJ, Qin A, Zhao Z and Tang BZ (2015). Modulation of aggregation-induced emission and electroluminescence of silole derivatives by a covalent bonding pattern. Chemistry. 21(22):8137-47.

  33. Shen Y, Hou Y, Yao S, Huang P and Yobas L (2015). In vitro epithelial organoid generation induced by substrate nanotopography. Sci Rep. 5:9293.

  34. Shi X, He BL, Ma AC, Guo Y, Chi Y, Man CH, Zhang W, Zhang Y, Wen Z, Cheng T and Leung AY (2015). Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Blood. 125(19):2974-84.

  35. Song H, Xu R and Guo Z (2015). Identification and characterization of a methionine γ-lyase in the calicheamicin biosynthetic cluster of Micromonospora echinospora. Chembiochem. 16(1):100-9.

  36. Tong Y, Yung LY and Wong YH (2015). Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis. Cancer Lett. 361(2):207-17.

  37. Wang E, He Z, Zhao E, Meng L, Schütt C, Lam JW, Sung HH, Williams ID, Huang X, Herges R and Tang BZ (2015). Aggregation-induced-emission-active macrocycle exhibiting analogous triply and singly twisted möbius topologies. Chemistry. 21(33):11707-11.

  38. Wang H, Zhao E, Lam WY and Tang BZ (2015). AIE luminogens: emission brightened by aggregation. Materials Today. 18(7):365-77.

  39. Wei W, Lu Y, Hao B, Zhang K, Wang Q, Miller AL, Zhang LR, Zhang LH and Yue J (2015). CD38 is required for neural differentiation of mouse embryonic stem cells by modulating reactive oxygen species. Stem Cells. 33(9):2664-73.

  40. Wei Z, Li Y, Ye F and Zhang M (2015). Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin. J Biol Chem. 290(18):11384-92.

  41. Wong WK, Kelly T, Li J, Ma HT and Poon RY (2015). SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56. Cell Cycle. 14(24):3965-77.

  42. Wu W, Wan OW and Chung KK (2015). S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function. Apoptosis. 20(4):491-9.

  43. Xie C, Cao X, Chen X, Wang D, Zhang WK, Sun Y, Hu W, Zhou Z, Wang Y and Huang P (2015). Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia. FASEB J. fj.15-283002.

  44. Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C and Pan L (2015). Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2. Autophagy. 11(10):1775-89.

  45. Xu J, Zhu L, He S, Wu Y, Jin W, Yu T, Qu JY and Wen Z (2015). Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish. Dev Cell. 34(6):632-41.

  46. Ye T, Fu AK and Ip NY (2015). Emerging roles of Axin in cerebral cortical development. Front Cell Neurosci. 8;9:217.

  47. Yuan H, Zhang T, Liu X, Deng M, Zhang W, Wen Z, Chen S, Chen Z, de The H, Zhou J and Zhu J (2015). Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Sci Rep. 5:9011.

  48. Zhang L, Silva DA, Pardo-Avila F, Wang D and Huang X (2015). Structural model of RNA polymerase II Elongation complex with complete transcription bubble reveals NTP entry routes. PLoS Comput Biol. 11(7):e1004354.

  49. Zhang P, Fu WY, Fu AK and Ip NY (2015). S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun. 6:8665.

  50. Zhang W, Kwok RT, Chen Y, Chen S, Zhao E, Yu CY, Lam JW, Zheng Q and Tang BZ (2015). Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics. Chem Commun (Camb). 51(43):9022-5.

  51. Zhao E, Chen Y, Chen S, Deng H, Gui C, Leung CW, Hong Y, Lam JW and Tang BZ (2015). A Luminogen with aggregation-induced emission characteristics for wash-free bacterial imaging, High-Throughput antibiotics screening and bacterial susceptibility evaluation. Adv Mater. 27(33):4931-7.

  52. Zhao E, Chen Y, Wang H, Chen S, Lam JW, Leung CW, Hong Y and Tang BZ (2015). Light-enhanced bacterial killing and wash-free imaging based on AIE fluorogen. ACS Appl Mater Interfaces. 7(13):7180-8.

  53. Zhao N, Chen S, Hong Y and Tang BZ (2015). A red emitting mitochondria-targeted AIE probe as an indicator for membrane potential and mouse sperm activity. Chem Commun (Camb). 51(71):13599-602.

  54. Zhao XS, Fu WY, Hung KW, Chien WW, Li Z, Fu AK and Ip NY (2015). NRC-interacting factor directs neurite outgrowth in an activity-dependent manner. Neuroscience. 289:207-13.

  55. Zhao Y, Yu CY, Kwok RT, Chen Y, Chen S, Lam JW and Tang BZ (2015). Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation. J Mater Chem B. 2015,3, 4993-4996.

  56. Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z and Feng G (2015). Mice with Shank3 mutations associated with ASD and Schizophrenia display both shared and distinct defects. Neuron. 89(1):147-62.

  57. Zhu Q, Zhang Y, Nie H, Zhao Z, Liu S, Wong KS and Tang BZ (2015). Insight into the strong aggregation-induced emission of low-conjugated racemic C6-unsubstituted tetrahydropyrimidines through crystal-structure–property relationship of polymorphs. Chem Sci. 2015, 6, 4690-7.

  58. Zuo H and Wong YH (2015). Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ. BMC Cancer. 15:775.

 
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  The State Key Laboratory of Neuroscience aims to become one of the world’s leading research hub in neuroscience research. From Bench to Bedside - Towards The Treatment of Debilitating Neurological Disorders Through The Discovery of Novel Neuro-Drugs.  
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