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  State Key Labratory of Molecular Neuroscience  
 
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Research Publications in 2014   spacer
   
  1. Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH and Carrillo MC (2014). 2014 Report on the milestones for the US National plan to address Alzheimer's disease. Alzheimers Dement. 10(5 Suppl):S430-52.

  2. Chan CY, Lam JW, Zhao Z, Chen S, Lu P, Sung HH, Kwok HS, Ma Y, Williams ID and Tang BZ (2014). Aggregation-induced emission, mechanochromism and blue electroluminescence of carbazole and triphenylamine-substituted ethenes. Journal of Materials Chemistry C. 2(21):4320-7.

  3. Chan KH, Chen YH, Zhang Y, Wong YH and Dun NJ (2014). Angiotensin-[1-12] interacts with angiotensin type I receptors. Neuropharmacology. 81:267-73.

  4. Chen H, Huang S, Han X, Zhang J, Shan C, Tsang YH, Ma HT and Poon RY (2014). Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death. Cell Death Dis. 5:e1177.

  5. Chen J and Herrup K (2014). Glutamine as a Potential Neuroprotectant in Alzheimer’s Disease. In: Diet and Nutrition in Dementia and Cognitive Decline, Chapter 70, Martin, Ed., Elsevier, Oxford. In press.

  6. Chen S, Hong Y, Liu J, Tseng NW, Liu Y, Zhao E, Lam JW and Tang BZ (2014). Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye. Journal of Materials Chemistry B. 2(25):3919-3923.

  7. Chen Y, Lam JW, Chen S and Tang BZ (2014). Synthesis, properties, and applications of poly(ethylene glycol)-decorated tetraphenylethenes. Journal of Materials Chemistry C. 2(30):6192-8.

  8. Choi YK and Qi RZ (2014). Assaying microtubule nucleation by the γ-tubulin ring complex. Methods Enzymol. 540:119-30.

  9. Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup K and Zhang J (2014). CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc Natl Acad Sci USA. 111(45):E4887-95.

  10. Diao Y, Guo X, Jiang L, Wang G, Zhang C, Wan J, Jin Y and Wu Z (2014). miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. J Biol Chem. 289(1):529-39.

  11. Ding Y, Yang M, Yang Z, Luo R, Lu X, Huang N, Huang P and Leng Y (2014). Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography. Acta Biomater. 15:150-63 (Epub 2014 Dec 23).

  12. Ding Y, Yang Z, Bi CW, Yang M, Xu SL, Lu X, Huang N, Huang P and Leng Y (2014). Directing vascular cell selectivity and hemocompatibility on patterned platforms featuring variable topographic geometry and size. ACS Appl Mater Interfaces. 6(15):12062-70.

  13. Ding Y, Yang Z, Bi CW, Yang M, Zhang J, Li X, Lu X, Huang N, Huang P and Leng Y (2014). Modulation of protein adsorption, vascular cell selectivity and platelet sdhesion by mussel-inspired surface functionalization. Journal of Materials Chemistry B. 2(24):3819-29.

  14. Fang WQ, Chen WW, Jiang L, Liu K, Yung WH, Fu AK and Ip NY (2014). Overproduction of upper-layer neurons in the neocortex leads to autism-like features in mice. Cell Rep. 9(5):1635-43.

  15. Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY and Ip NY (2014). Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci USA. 111(27):9959-64.

  16. Goto S, Kamal N, Puzio H, Kobylarz F and Herrup K (2014). Differential responses of individuals with late-stage dementia to two novel environments: a multimedia room and an interior garden. J Alzheimers Dis. 42(3):985-98.

  17. Gu S, Silva DA, Meng L, Yue A and Huang X (2014). Quantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysis. PLoS Comput Biol. 10(8):e1003767.

  18. Hu Y, Chan KH, He X, Ho MK and Wong YH (2014). Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands. PLoS One. 9(12):e113638.

  19. Ip FC, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH and Ip NY (2014). Cycloastragenol is a potent telomerase activator in neuronal cells: Implications for depression management. Neurosignals. 22(1):52-63.

  20. Jehi SE, Li X, Sandhu R, Ye F, Benmerzouga I, Zhang M, Zhao Y and Li B (2014). Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity. Nucleic Acids Res. 42(20):12899-911.

  21. Kwok RT, Geng J, Lam JW, Zhao E, Wang G, Zhan R, Liu B and Tang BZ (2014). Water-soluble bioprobes with aggregation-induced emission characteristics for light-up sensing of heparin. Journal of Materials Chemistry B. 2(26):4134-41.

  22. Li S, He Q, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH and Liu K (2014). Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiol Dis. 73C:366-376.

  23. Li Y, Wei Z, Yan Y, Wan Q, Du Q and Zhang M (2014). Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Proc Natl Acad Sci USA. 111(49):17444-9.

  24. Li Y, Wei Z, Zhang J, Yang Z and Zhang M (2014). Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1. J Biol Chem. 289(21):14674-81.

  25. Liu P, Choi YK and Qi RZ (2014). NME7 is a functional component of the γ-tubulin ring complex. Mol Biol Cell. 25(13):2017-25.

  26. Liu Y, Gao M, Lam JW, Hu R and Tang BZ (2014). Copper-Catalyzed polycoupling of diynes, primary amines, and aldehydes: A new one-pot multicomponent polymerization tool to functional polymers. Macromolecules. 47:4908-19.

  27. Lo WS, Gardiner E, Xu Z, Lau CF, Wang F, Zhou JJ, Mendlein JD, Nangle LA, Chiang KP, Yang XL, Au KF, Wong WH, Guo M, Zhang M and Schimmel P (2014). Human tRNA synthetase catalytic nulls with diverse functions. Science. 345(6194):328-32.

  28. Lu Q, Li J and Zhang M (2014). Cargo recognition and cargo-mediated regulation of unconventional myosins. Acc Chem Res. 47(10):3061-70.

  29. Lu Q, Li J, Ye F and Zhang M (2014). Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat Struct Mol Biol. 22(1):81-8. (Epub 2014 Dec 1).

  30. Ma HT, Erdal S, Huang S and Poon RY (2014). Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance. Mol Oncol. 8(8):1404-18.

  31. Mak JP, Man WY, Ma HT and Poon RY (2014). Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget. 5(21):10546-57.

  32. Man WY, Mak JP and Poon RY (2014). Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint. J Cell Mol Med. 18(1):143-55.

  33. Marxer M, Ma HT, Man WY and Poon RY (2014). p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases. Oncogene. 33(27):3550-60.

  34. Poon RY (2014). DNA damage checkpoints in nasopharyngeal carcinoma. Oral Oncol. 50(5):339-44.

  35. Qin W, Liu J, Chen S, Lam JW, Arseneault M, Yang Z, Zhao Q, Kwok HS and Tang BZ (2014). Crafting NPB with tetraphenylethene: a win–win strategy to create stable and efficient solid-stateemitters with aggregation-induced emission feature, high hole-transporting property andefficient electroluminescence. Journal of Materials Chemistry C. 2(19): 3756-61.

  36. Shen Y, Hou Y, Yao S, Huang P and Yobas L (2014). The effect of micropattern topography on epithelial lumen formation. Scientific Reports. In press.

  37. Silva DA, Weiss DR, Pardo Avila F, Da LT, Levitt M, Wang D and Huang X (2014). Millisecond dynamics of RNA polymerase II translocation at atomic resolution. Proc Natl Acad Sci USA. 111(21):7665-70.

  38. Song Z, Hong Y, Kwok RT, Lam JW, Liu B and Tang BZ (2014). A dual-mode fluorescence “turn-on” biosensor based on an aggregation-induced emission luminogen. J. Mater. Chem. B. 2(12):1717-23.

  39. Song Z, Kwok RT, Zhao E, He Z, Hong Y, Lam JW, Liu B and Tang BZ (2014). A ratiometric fluorescent probe based on ESIPT and AIE processes for alkaline phosphatase activity assay and visualization in living cells. ACS Appl Mater Interfaces. 6(19):17245-54.

  40. Sun Y, Yin S, Feng Y, Li J, Zhou J, Liu C, Zhu G and Guo Z (2014). Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad. J Biol Chem. 289(22):15867-79.

  41. Tang J, Ip JP, Ye T, Ng YP, Yung WH, Wu Z, Fang W, Fu AK and Ip NY (2014). Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition. J Neurosci. 34(22):7425-36.

  42. Tse KH, Chow KB, Leung WK, Wong YH and Wise H (2014). Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways. Neuroscience. 267:241-51.

  43. Tse KH, Chow KB, Leung WK, Wong YH and Wise H (2014). Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia. Neuroscience. 279:10-22.

  44. Wang C, Wei Z, Chen K, Ye F, Yu C, Bennett V and Zhang M (2014). Structural basis of diverse membrane target recognitions by ankyrins. eLife. 3:e04353.

  45. Wang XQ, Chan KK, Ming X, Lui VC, Poon RY, Lo CM, Norbury C and Poon RT (2014). G1 checkpoint establishment in vivo during embryonic liver development. BMC Dev Biol. 14:23.

  46. Wang Z, Zhang C and Qi RZ (2014). A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport. J Cell Sci. 127(22):4904-17.

  47. Webb SE, Goulet C, Chan CM, Yuen MY and Miller AL (2014). Biphasic assembly of the contractile apparatus during the first two cell division cycles in zebrafish embryos. Zygote. 22(2):218-28.

  48. Wu H, Li H, Kwok RT, Zhao E, Sun JZ, Qin A and Tang BZ (2014). A recyclable and reusable supported Cu(I) catalyzed azide-alkyne click polymerization. Sci Rep. 4:5107.

  49. Xing X, Poon RY, Wong CS and Yobas L (2014). Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes. Biosens Bioelectron. 61:434-42.

  50. Xu L, Zhang L, Chong J, Xu J, Huang X and Wang D (2014). Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity. Proc Natl Acad Sci USA. 111(32):E3269-76.

  51. Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, Zhang W, Li L and Wen Z(2014). IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model. J Immunol. 192(12):5998-6008.

  52. Yang Y, Hui CW, Li J and Herrup K (2014). The interaction of the atm genotype with inflammation and oxidative stress. PLoS One. 9(1):e85863.

  53. Yu CY, Kwok RT, Mei J, Hong Y, Chen S, Lam JW and Tang BZ (2014). A tetraphenylethene-based caged compound: synthesis, properties and applications. Chem Commun (Camb). 50(60):8134-6.

  54. Zeng Y, Yan B, Sun Q, He S, Jiang J, Wen Z and Qu JY (2014). In vivo micro-vascular imaging and flow cytometry in zebrafish using two-photon excited endogenous fluorescence. Biomed Opt Express. 5(3):653-63.

  55. Zeng Y, Yan B, Xu J, Sun Q, He S, Jiang J, Wen Z and Qu JY(2014). In Vivo nonlinear optical imaging of immune responses: tissue injury and infection. Biophys J. 107(10):2436-43.

  56. Zhang C, Kho YS, Wang Z, Chiang YT, Ng GK, Shaw PC, Wang Y and Qi RZ (2014). Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. PLoS One. 9(1):e85206.

  57. Zhang L, Silva DA, Zhang H, Yue A, Yan Y and Huang X (2014). Dynamic protein conformations preferentially drive energy transfer along the active chain of the photosystem II reaction centre. Nat Commun. 5:4170.

  58. Zhang X, Xiao D, Wang Z, Zou Y, Huang L, Lin W, Deng Q, Pan H, Zhou J, Liang C and He J (2014). MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer. Mol Cancer Res. 12(11):1535-46.

  59. Zhou JJ, Wang F, Xu Z, Lo WS, Lau CF, Chiang KP, Nangle LA, Ashlock MA, Mendlein JD, Yang XL, Zhang M and Schimmel P (2014). Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis. J Biol Chem. 289(28):19269-75.

  60. Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q and Zhang M (2014). Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl. Cell Res. 24(4):451-63.

 
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  The State Key Laboratory of Neuroscience aims to become one of the world’s leading research hub in neuroscience research. From Bench to Bedside - Towards The Treatment of Debilitating Neurological Disorders Through The Discovery of Novel Neuro-Drugs.  
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